Muriel Boube

This paper shows that increasing Med19 in Drosophila extends lifespan by 90%, delays frailty onset, and improves stress resistance, while reducing Med19 shortens lifespan and increases vulnerability to stress.

The paper identifies Pri smORF peptides as pleiotropic regulators of leg development in Drosophila, functioning through Ubr3-dependent and -independent mechanisms in patterning and cell survival.

This study uses inducible degradation of Med19 in Drosophila to show it specifically regulates developmental genes but not constitutively expressed genes.

The paper investigates how enhancers regulate duplicated genes in Drosophila, showing differential activity and evolutionary conservation between tissue-specific and pleiotropic enhancers.

The paper shows Med19 interacts with GATA TFs' zinc fingers and is critical for GATA-dependent gene regulation, distinct from Med1's role.

This study identifies CDK8-CycC's role in Drosophila wing vein patterning by interacting with the Dpp/TGF{beta} pathway and regulating Mad-dependent transcription.