Loop-Directed Cofactor Binding Enables Programmable Multico-factor Protein Design
Andrew C. Mutter, Aleksandr Uvaydov, Eskil M. E. Andersen, Sara Morsi, Sarah Beck, Mohammad Khan, Bruce Allan Palfey, Carolyn E. Lubner, Ronald L. Koder
This paper designs proteins with multiple cofactor binding sites by placing histidine ligands in loop regions, enabling precise control over cofactor positioning and function.
bioRxiv · Jun 28, 2026 · PreprintBiophysics