Targeted therapy-induced chromosomal instability dictates mitotic dependency on Aurora Kinase A
Chendi Li, Varuna Nangia, Melissa D Vieira, Anahita Nimbalkar, Christopher J. Graser, Jeremy B. Chang, Mohammad U. Syed, Yi Shen, Radhika Koranne, Lee Zou, Xueqian Gong, Sabrina L. Spencer, Aaron N. Hata
This study shows that KRASG12C inhibition induces chromosomal instability (CIN) in NSCLC cells, which synergizes with Aurora Kinase A inhibition to enhance therapeutic efficacy.
bioRxiv · Jan 23, 2026 · PreprintCancer Biology