Lee Zou

This study identifies SIRT5-induced metabolic changes as a driver of chemoresistance in TNBC and reveals ATR checkpoint dependence as a therapeutic vulnerability.

This study identifies BRCA1-A and LIG4 complexes as mediators of ecDNA biogenesis and shows their role in cancer drug resistance.

This study shows that KRASG12C inhibition induces chromosomal instability (CIN) in NSCLC cells, which synergizes with Aurora Kinase A inhibition to enhance therapeutic efficacy.

The paper shows that AR inhibition in prostate cancer causes DNA replication stress, which can be exploited by combining with a TLS inhibitor to enhance treatment efficacy.

The paper shows genomic uracil induces DNA replication stress without BER processing and identifies UNG2 upregulation as a vulnerability in cancer cells.

This study identifies RAP80 as a suppressor of R-loop vulnerability during DNA double-strand break repair, preventing genomic abnormalities.