LRRK2 kinase inhibition protects against Parkinson's disease-associated environmental toxicants
Neda M. Ilieva, Eric K. Hoffman, Mohammed Ghalib, J. Timothy Greenamyre, Briana R. De Miranda
This study shows that inhibiting LRRK2 kinase activity reduces ROS and protects against mitochondrial toxicity from environmental toxicants in both in vitro and in vivo models of Parkinson's disease.
Neurobiology of Disease · May 3, 2024Peer-reviewedNeuroscience