Eric K. Hoffman

This study identifies 15-lipoxygenase-mediated lipid peroxidation as a regulator of LRRK2 kinase activity, linking it to Parkinson's disease pathogenesis.

This study shows that inhibiting LRRK2 kinase activity reduces ROS and protects against mitochondrial toxicity from environmental toxicants in both in vitro and in vivo models of Parkinson's disease.

The paper demonstrates that neuronal NOX2 contributes to oxidative stress, α-synuclein pathology, and LRRK2 activation in Parkinson's disease and shows that NOX2 inhibitors can prevent these effects in a rat model.