RNA-Binding Protein NF90 Mediates Polycomb-Independent Transactivation by EZH2 to Promote Cancer Growth
Yuan Wang, Peng Liu, Xiaodong Lü, Hongshun Shi, Mohan Zheng, Sambhavi Senthil, Jawad Akhtar, Yongik Lee, Hana Chandonnet, Jonathan D. Licht, Ximing J. Yang, Jonathan C. Zhao, Jindan Yu
This study identifies NF90 as a coactivator of EZH2's polycomb-independent transactivation function in prostate cancer, promoting cell growth and poor clinical outcomes.
bioRxiv · Dec 3, 2025 · PreprintCell Biology