Yuan Wang

Quality control at the Golgi couples membrane proteostasis to lipid metabolism

The paper identifies a Golgi quality control checkpoint in yeast that links membrane proteostasis to lipid metabolism, showing that lipid imbalance from proteostasis defects is lethal.

ATR is a master regulator of the oocyte meiotic prophase checkpoint

This study identifies ATR as a master regulator of the oocyte meiotic prophase checkpoint and defines a BRCA1-ATR signaling axis linking chromosome asynapsis to oocyte elimination.

FLASH X-rays preserve neutrophil chromatin to boost antitumor immunity

This study shows FLASH X-rays preserve neutrophil chromatin, reducing NET formation and enhancing antitumor immunity when combined with anti-PD-1 therapy.

RNA-Binding Protein NF90 Mediates Polycomb-Independent Transactivation by EZH2 to Promote Cancer Growth

This study identifies NF90 as a coactivator of EZH2's polycomb-independent transactivation function in prostate cancer, promoting cell growth and poor clinical outcomes.

Therapeutic Potential of a Tectorigenin Derivative (TED) in Herpetic Stromal Keratitis: Antiviral and lmmunomodulatory Mechanisms

This study evaluates TED's anti-HSV-1 effects and therapeutic efficacy in HSK, finding it reduces viral loads and modulates immune responses through TLR pathway inhibition and immune cell regulation.

Structures of PSI-FCPI from Thalassiosira pseudonana in high light provide convergent evolution and light-adaptive strategies in diatom FCPIs

The paper reports cryo-EM structures of PSI-FCPI complexes from Thalassiosira pseudonana under high light, revealing light-adaptive strategies and convergent evolution in diatom FCPIs.

Calcium-independent but voltage-dependent secretion (CiVDS) mediates synaptic transmission in a mammalian central synapse

The paper demonstrates that CiVDS contributes to central synaptic transmission by mediating a significant portion of EPSCs in a mammalian central synapse.