Jawad Akhtar

SMYD3 protein degraders in HPV-negative head and neck squamous cell carcinoma.

This study develops SMYD3 proteolysis targeting chimeras (PROTACs) for HPV-negative head and neck squamous cell carcinoma, showing effective SMYD3 degradation and reduced oncogenic activity.

Oncogenic and immunomodulatory functions of SUV420H1 in HPV-negative head and neck squamous cell carcinoma.

This study identifies SUV420H1 as a driver in HPV-negative HNSCC, showing its role in proliferation, invasion, and immune evasion, and suggests targeting it to improve immunotherapy response.

RNA-Binding Protein NF90 Mediates Polycomb-Independent Transactivation by EZH2 to Promote Cancer Growth

This study identifies NF90 as a coactivator of EZH2's polycomb-independent transactivation function in prostate cancer, promoting cell growth and poor clinical outcomes.

Genome-wide binding of Multiple ankyrin repeats single KH domain reveals its role in maintenance of gene activation by trithorax group proteins in Drosophila

This study identifies Mask as a downstream effector of Trithorax group proteins in Drosophila, showing its role in maintaining gene activation by regulating H3K27ac and H3K27me3 levels.

Polycomb requires Tcp-1η chaperonin for maintaining gene silencing in Drosophila

This study identifies Tcp-1η as a chaperonin subunit that interacts with Polycomb to maintain gene silencing in Drosophila, supporting its role in PcG targeting and chromatin association.

Kinome-wide RNAi screen uncovers role of Ballchen in maintenance of gene activation by trithorax group in Drosophila

The paper identifies Ballchen as a trithorax group regulator that counteracts Polycomb group repression by maintaining gene activation through histone modification.