EPOP Restricts PRC2.1 Targeting to Chromatin by Directly Modulating Enzyme Complex Dimerization
Lihu Gong, Xiuli Liu, Xin Yang, Ze Yu, Mohd Younus Bhat, Siming Chen, Andrew S. Lemoff, Chao Xing, Xin Liu
The paper shows EPOP inhibits PRC2.1 by disrupting its dimerization, reducing chromatin association, and preventing over-repression of gene regulators during early differentiation.
Nature Communications · Jan 10, 2026Peer-reviewedMolecular Biology