The paper shows EPOP inhibits PRC2.1 by disrupting its dimerization, reducing chromatin association, and preventing over-repression of gene regulators during early differentiation.

Nature Communications · Jan 10, 2026Peer-reviewedMolecular Biology

YY1 relieves p300 autoinhibition to promote histone acetylation in advanced prostate cancer, enhancing the oncogenic signaling of Androgen Receptor Splice Variant 7

Chenxi Xu, Dongyu Wu, Bo Pan, Xiaoxiao Ren, Samuel G. Mackintosh, Kanishk Jain, Natarajan V. Bhanu, Ricky D. Edmondson, Xin Liu, Benjamin Aaron Garcia, Alan J. Tackett, Jian Jun Jin, Gang Greg Wang, Ling Cai

This study shows YY1 enhances p300 acetyltransferase activity in CRPC, promoting histone acetylation and oncogenic gene expression, and identifies a potential therapeutic target for overcoming drug resistance.

bioRxiv · Aug 4, 2025 · PreprintCancer Biology

Interrogation of Enhancer Function by Enhanced CRISPR Epigenetic Editing

Kailong Li, Yuxuan Liu, Hui Cao, Yuannyu Zhang, Zhimin Gu, Xin Liu, Andy Yu, Pranita Kaphle, Kathryn E. Dickerson, Min Ni, Jian Xu

This paper introduces enhanced CRISPR epigenetic editing systems to analyze enhancer function in vivo, showing improved modulation of gene transcription with minimal off-target effects.

bioRxiv · Sep 8, 2019 · PreprintMolecular Biology

Dissecting super-enhancer hierarchy based on chromatin interactions

Jialiang Huang, Kailong Li, Wenqing Cai, Xin Liu, Yuannyu Zhang, Stuart H. Orkin, Jian Xu, Guo‐Cheng Yuan

The paper identifies hub enhancers within super-enhancers using Hi-C and ChIP-seq data, showing their role in gene activation and chromatin structure.

Nature Communications · Feb 27, 2018Peer-reviewedBioinformatics