Siming Chen

The paper shows EPOP inhibits PRC2.1 by disrupting its dimerization, reducing chromatin association, and preventing over-repression of gene regulators during early differentiation.

CellHermes integrates multimodal omics data using a biological language model, achieving comparable or better performance than single-cell models across various tasks.

This study shows PCL proteins phase-separate to form PRC2 condensates, regulated by CpG islands disrupting their intramolecular interactions.

This study shows that homoharringtonine promotes FTO degradation, reducing LILRB4 expression and enhancing immune recognition in acute monocytic leukemia.