Measuring the impact of genetic heterogeneity and chromosomal inversions on the efficacy of CRISPR-Cas9 gene drives in different strains of Anopheles gambiae
Poppy Pescod, Giulia Bevivino, Amalia Anthousi, Ruth Shelton, Molly Margiotta, Josephine Shepherd, Fabrizio Lombardo, Tony Nolan
This study evaluates how genetic variation and chromosomal inversions affect CRISPR-Cas9 gene drive homing in Anopheles gambiae strains, finding no significant reduction in homing despite target site heterogeneity.
The CRISPR Journal · Sep 13, 2023Peer-reviewedGenetics