Forced isoform switching of Neat1_1 to Neat1_2 leads to the loss of Neat1_1 and the hyperformation of paraspeckles but does not affect the development and growth of mice
Momo Isobe, Hikaru Toya, Mari Mito, Tomoki Chiba, Hiroshi Asahara, Tetsuro Hirose, Shinichi Nakagawa
This study shows that switching Neat1 isoforms from Neat1_1 to Neat1_2 in mice leads to loss of Neat1_1, increased Neat1_2, and hyperformed paraspeckles without affecting mouse development or growth.
RNA · Dec 10, 2019Peer-reviewedMolecular Biology