Tomoki Chiba

This study shows that tendon-specific PIEZO1 activation increases neural drive to muscle during high-load ballistic movements, without affecting muscle mass or myogenic gene expression.

This study identifies NAT10 as a regulator of CAG repeat-containing mRNA stability and links its upregulation in spaceflight to metabolic reprogramming in mouse liver.

This study introduces TEMPO-editing, a method to generate multiple-gene-edited mice in a single step, demonstrating its effectiveness in creating double-gene-edited mice with spatial and temporal specificity.

This study identifies CD55 and CD248 as novel surface markers for tendon stem/progenitor cells using single-cell and single-nucleus sequencing in mouse Achilles tendon.

This study shows neuronal micronuclei influence microglial states by altering their morphology and transcriptome during postnatal development.

This study identifies KLF4 as a potential transcriptional regulator of angiogenesis and neural development in sevoflurane-exposed mice brains.

The paper identifies TruB1 as a regulator of let-7 miRNA maturation and function, showing it enhances let-7 processing through direct interaction with pri-let-7.

This study shows that switching Neat1 isoforms from Neat1_1 to Neat1_2 in mice leads to loss of Neat1_1, increased Neat1_2, and hyperformed paraspeckles without affecting mouse development or growth.

The paper investigates the roles of NEAT1 isoforms, finding that NEAT1_1 is dispensable for tissue homeostasis and cancer cell growth, while NEAT1_2 is critical for paraspeckle formation and function.