Tetsuro Hirose

The paper identifies how arcRNAs organize functional proteins through molecular concentration and activated enzyme selection in nuclear stress bodies.

The paper identifies phosphorylation events and thermosensing mechanisms that regulate CLK1 localization to nuclear stress bodies during thermal stress recovery.

The paper identifies blocky proline/glutamine patterns in the SFPQ IDR as essential for paraspeckle formation and segregation from nuclear speckles through phase separation.

This study identifies cytoplasmic roles of HSATIII RNAs in forming RNA granules and producing proteins during thermal stress recovery.

This study identifies a novel interaction between AGO1 and NEAT1 lncRNA, showing their roles in nuclear compartmentalization and chromatin organization.

This study identifies huntingtin as an RNA-binding protein that interacts with G-rich RNA sequences, including those in the NEAT1 paraspeckle lncRNA.

The paper identifies 1,074 semi-extractable RNAs across five human cell lines and characterizes their distribution, interactions, and grouping based on k-mer content.

The paper introduces a method to detect readthrough downstream-of-gene transcripts by semi-extractable RNA-seq and identifies stress-inducible, semi-extractable transcripts.

The paper identifies SPF45/RBM17 as essential for splicing a subset of human short introns, showing it competes with U2AF65 for binding to SF3B1, while U2AF is not required for this process.

This paper investigates how paraspeckles form through microphase separation, showing they behave like block copolymer micelles.

The paper functionally annotates human long non-coding RNAs by systematically knocking down 285 lncRNAs and analyzing molecular phenotypes using CAGE sequencing.

This study shows that NEAT1 regulates adaptive behavioural responses to stress in mice by affecting neuronal function and gene expression.

This study shows that switching Neat1 isoforms from Neat1_1 to Neat1_2 in mice leads to loss of Neat1_1, increased Neat1_2, and hyperformed paraspeckles without affecting mouse development or growth.

The paper shows that lncRNA-dependent nuclear stress bodies promote intron retention via SR protein phosphorylation during thermal stress recovery.

The paper investigates the roles of NEAT1 isoforms, finding that NEAT1_1 is dispensable for tissue homeostasis and cancer cell growth, while NEAT1_2 is critical for paraspeckle formation and function.

This study shows AGO1 and NEAT1 lncRNA maintain 3D chromatin architecture by regulating TADs and A/B compartments in human cells.