Shinichi Nakagawa

This study shows oxytocin signaling is essential for maturing TN-GnRH3 circuits and regulating mate preference in medaka, with C1q-dependent synaptic mechanisms involved.

This study investigates the role of coilin in mice by generating coilin mutants, revealing its involvement in snRNA modifications and the formation of novel condensates in spermatids.

The paper identifies a unique Hmgn2 variant in medaka fish that influences shape preference behavior through altered subnuclear localization and telencephalon development.

The paper investigates paraspeckle formation in naked mole-rats, finding that nNEAT1_2 recruits different RNA binding proteins compared to mice.

This paper investigates how paraspeckles form through microphase separation, showing they behave like block copolymer micelles.

This study shows that NEAT1 regulates adaptive behavioural responses to stress in mice by affecting neuronal function and gene expression.

This study shows that switching Neat1 isoforms from Neat1_1 to Neat1_2 in mice leads to loss of Neat1_1, increased Neat1_2, and hyperformed paraspeckles without affecting mouse development or growth.

The paper identifies NSUN2 as a methyltransferase that introduces 5-methylcytidine into mitochondrial tRNAs in mice and humans.

The paper investigates the roles of NEAT1 isoforms, finding that NEAT1_1 is dispensable for tissue homeostasis and cancer cell growth, while NEAT1_2 is critical for paraspeckle formation and function.

The paper introduces UPA-Seq, a method to predict functional lncRNAs by measuring their differential sensitivity to UV crosslinking, finding that lncRNAs with greater UV sensitivity associate more with PrLD-containing proteins.

The paper introduces tChIP-Seq, a method to analyze cell type-specific epigenetic modifications, identifying neuronal genes and unknown functions in cortical neurons.