Hiroshi Asahara

Tendon-specific PIEZO1 activation enhances neural drive to muscle during ballistic movement

This study shows that tendon-specific PIEZO1 activation increases neural drive to muscle during high-load ballistic movements, without affecting muscle mass or myogenic gene expression.

Integrated transcriptomic and epigenomic profiling of human cartilage reveals coordinated changes in fibronectin expression, splicing, and receptor signaling during osteoarthritis progression

This study profiles human cartilage across OA grades, revealing changes in fibronectin expression, splicing, and receptor signaling during disease progression.

Single-nucleus multiome profiling reveals osteocyte-centered remodeling of human subchondral bone across osteoarthritis severity

The paper uses single-nucleus multiome sequencing to analyze subchondral bone in OA, finding increased osteocyte SMAD2/3 activity and chondrocyte-derived FN1 signaling with disease severity.

NAT10 supports CAG repeat-associated mRNA stabilization and is associated with hepatic metabolic reprogramming during spaceflight

This study identifies NAT10 as a regulator of CAG repeat-containing mRNA stability and links its upregulation in spaceflight to metabolic reprogramming in mouse liver.

One-step generation of mice by Transposon-Enhanced Multi-Plex Orchestration Editing(TEMPO-Editing)

This study introduces TEMPO-editing, a method to generate multiple-gene-edited mice in a single step, demonstrating its effectiveness in creating double-gene-edited mice with spatial and temporal specificity.

Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells

This study identifies CD55 and CD248 as novel surface markers for tendon stem/progenitor cells using single-cell and single-nucleus sequencing in mouse Achilles tendon.

Scx-positive tendon cells are required for correct muscle patterning

This study shows that Scx-positive tendon cells are essential for proper muscle attachment and patterning in mouse embryos, revealing a novel tissue-tissue interaction in musculoskeletal development.

Transcriptome analysis of sevoflurane exposure effects at the different brain regions

This study identifies KLF4 as a potential transcriptional regulator of angiogenesis and neural development in sevoflurane-exposed mice brains.

The tRNA pseudouridine synthase TruB1 regulates the maturation and function of let-7 miRNA

The paper identifies TruB1 as a regulator of let-7 miRNA maturation and function, showing it enhances let-7 processing through direct interaction with pri-let-7.

Lin28a/let-7 Pathway Modulates the Hox Code via Polycomb Regulation during Axial Patterning in Vertebrates

This study shows the Lin28a/let-7 pathway regulates Hox gene expression during axial patterning by modulating Polycomb complex occupancy in vertebrates.

Forced isoform switching of Neat1_1 to Neat1_2 leads to the loss of Neat1_1 and the hyperformation of paraspeckles but does not affect the development and growth of mice

This study shows that switching Neat1 isoforms from Neat1_1 to Neat1_2 in mice leads to loss of Neat1_1, increased Neat1_2, and hyperformed paraspeckles without affecting mouse development or growth.

The lncRNA NEAT1_1 is dispensable for normal tissue homeostasis and cancer cell growth

The paper investigates the roles of NEAT1 isoforms, finding that NEAT1_1 is dispensable for tissue homeostasis and cancer cell growth, while NEAT1_2 is critical for paraspeckle formation and function.