In Silico Determined Properties of Designed Superoxide Dismutase-1 Mutants Predict ALS-like Phenotypes In Vitro and In Vivo
Michèle G. DuVal, Luke McAlary, Mona Habibi, Pranav Garg, Mine Sher, Neil R. Cashman, W. Ted Allison, Steven S. Plotkin
The paper designs and tests SOD1 mutants using computational methods, showing that a destabilizing mutant causes ALS-like phenotypes while a stabilizing mutant rescues them in zebrafish.
bioRxiv · Nov 21, 2018 · PreprintBiophysics