Michèle G. DuVal

Subfunctionalization of tbx2 paralogues during photoreceptor cell specification in zebrafish

The paper shows that tbx2a and tbx2b subfunctionally regulate photoreceptor cell fate in zebrafish, with tbx2b promoting sws1 cone differentiation and tbx2a involved in regeneration.

Matrix metalloproteinases proteolyze RAB proteins and contribute to cisplatin-induced ototoxicity

This study shows MMP-2 and MMP-9 contribute to cisplatin-induced ototoxicity by cleaving RAB proteins, and inhibiting them improves hair cell survival.

Seizures are a druggable mechanistic link between TBI and subsequent tauopathy

This study shows that post-traumatic seizures and dynamin-dependent endocytosis promote tauopathy spread after TBI using a zebrafish model.

In Silico Determined Properties of Designed Superoxide Dismutase-1 Mutants Predict ALS-like Phenotypes In Vitro and In Vivo

The paper designs and tests SOD1 mutants using computational methods, showing that a destabilizing mutant causes ALS-like phenotypes while a stabilizing mutant rescues them in zebrafish.