Systematic Metaproteomics Mapping Reveals Functional and Ecological Landscapes of Ex Vivo Human Gut Microbiota Responses to Therapeutic Drugs
Leyuan Li, Caitlin M. A. Simopoulos, Janice Mayne, Zhibin Ning, Xin Zhang, Mona Hamada, James Butcher, Joeselle M. Serrana, Luman Wang, Kai Cheng, Hongye Qin, Krystal Walker, Xu Zhang, Alain P. Stintzi, Daniel Figeys
This study maps metaproteomic responses of human gut microbiota to 312 drugs, identifying 47 compounds that significantly alter microbial protein profiles and reveal functional state shifts.
Nature Communications · Oct 23, 2025Peer-reviewedMicrobiology