Spatiotemporal atlas of pro-inflammatory (NF-kB) and anti-inflammatory (STAT6) signalling using reporter mice during mRNA vaccination
Electra Brunialti, Alessia Panzeri, Nicoletta Rizzi, Alessandro Maria Villa, Clara Meda, Chiara Sfogliarini, Stefano Persano, Federico Arlati, Maria L. Guevara Lopez, Cristina Martelli, Gaetano Cannavale, Monica Rebecchi, Clara Di Vito, Letizia Venturini, Luisa Ottobrini, , Paolo Ciana
This paper develops a dual-reporter mouse system to analyze NF-kB and STAT6 signaling dynamics during mRNA vaccination, revealing liver as a key early hub and linking early STAT6 activation to robust humoral responses.
Molecular Therapy · Jun 2, 2026Peer-reviewedImmunology