Drug-repurposing screen identifies thiostrepton as a novel regulator of the tumor suppressor DAB2IP
Rossella De Florian Fania, Serena Maiocchi, Raffaella Klima, Monica Rossin, Valeria Pellegrini, Sabrina Ghetti, Davide Selvestrel, Maria Chiara Mattevi, Luca L. Fava, Luca Braga, Licio Collavin
The paper screens FDA-approved drugs to find those that increase DAB2IP protein levels, identifying thiostrepton as a potential anti-cancer agent that relies on DAB2IP for its tumor-suppressive effect.
Biomolecules · Aug 8, 2025Peer-reviewedCancer Biology