Luca L. Fava

Human iPSC-derived liver organoids model multicellular tissue responses and therapeutic rescue in Wolman disease

This study uses human liver organoids to model Wolman disease, showing multicellular interactions drive disease features and therapeutic responses.

Centrosome architecture and m6A-dependent gating of p53 surveillanceafter whole-genome doubling

The paper investigates how centrosome architecture and m6A-dependent regulation influence p53 surveillance after whole-genome doubling, identifying key molecular mechanisms.

Drug-repurposing screen identifies thiostrepton as a novel regulator of the tumor suppressor DAB2IP

The paper screens FDA-approved drugs to find those that increase DAB2IP protein levels, identifying thiostrepton as a potential anti-cancer agent that relies on DAB2IP for its tumor-suppressive effect.

A TranSNP in the DDIT4 mRNA can impact its translation efficiency and modulate p53-dependent responses in cancer cells

The paper identifies a tranSNP in DDIT4 mRNA that affects translation efficiency and modulates p53-dependent responses in cancer cells.

Caspase-2 kills cells with extra centrosomes

The paper shows that caspase-2 triggers apoptosis in cells with extra centrosomes, preventing polyploidization through mitochondrial pathways.