Adeno-Associated Virus 2 (AAV2) - induced RPA exhaustion generates cellular DNA damage and restricts viral gene expression
Monnette F. Summers, MegAnn K. Haubold, Marcel Morgenstern, Phoenix M. Shepherd, Clairine I. S. Larsen, Ava E. Bartz, Gopishankar Thirumoorthy, Robert N. Kirchdoerfer, Joshua J. Coon, Kavi P.M. Mehta, Kinjal Majumder
This study shows that AAV2 genomes compete with host RPA for binding, causing replication stress and DNA damage, which suppresses viral gene expression.
PLoS Pathogens · Aug 18, 2025Peer-reviewedMicrobiology