Author

Gopishankar Thirumoorthy

University of Wisconsin SystemORCID 0000-0003-0508-623XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Clairine I. S. Larsen· 2 shared Kinjal MajumderiD· 2 shared Ava E. Bartz· 1 shared David M. GammiD· 1 shared Divya SinhaiD· 1 shared Eda Erata· 1 shared Eleanor Hart· 1 shared Elizabeth K. Hofer· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMicrobiology

Clairine I. S. Larsen

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintJun 3, 2026

CTCF regulates wild-type and recombinant AAV gene expression by shaping viral chromatin

Clairine I. S. Larsen, Rhiannon R. Abrahams, Rea Guertler…·Kinjal Majumder

This study identifies a CTCF-binding element in the wtAAV2 genome that enhances rAAV transgene expression by shaping chromatin structure, offering a strategy to improve gene therapy vectors.

DOI 10.64898/2026.06.03.729793

DNA methylationHi-C

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MicrobiologyPLoS PathogensPeer-reviewedAug 18, 2025

Adeno-Associated Virus 2 (AAV2) - induced RPA exhaustion generates cellular DNA damage and restricts viral gene expression

Monnette F. Summers, MegAnn K. Haubold, Marcel Morgenstern…·Kinjal Majumder

This study shows that AAV2 genomes compete with host RPA for binding, causing replication stress and DNA damage, which suppresses viral gene expression.

5 citations

humanproteomics

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