Kavi P.M. Mehta

A TSST 1 structural motif disrupts endothelial programs required for vascular regeneration.

This study shows TSST-1 disrupts endothelial regeneration by impairing migration, cytoskeletal organization, and angiogenic sprouting, leading to non-healing vascular lesions.

Adeno-Associated Virus 2 (AAV2) - induced RPA exhaustion generates cellular DNA damage and restricts viral gene expression

This study shows that AAV2 genomes compete with host RPA for binding, causing replication stress and DNA damage, which suppresses viral gene expression.

SLX4IP acts in parallel to FANCM to limit BLM-dependent replication stress at ALT telomeres

This study identifies SLX4IP as a suppressor of BLM-driven replication stress at ALT telomeres and reveals its parallel function with FANCM to regulate telomere maintenance.

Hierarchical determinants of the oxidation-induced mutational landscape in human cells.

This study identifies factors influencing 8-oxoG-induced mutagenesis in human cells, revealing a hierarchical DNA repair network and chromatin structure effects on mutation patterns.

Self-reversal facilitates the resolution of HMCES-DNA protein crosslinks in cells

The paper shows that HMCES-DNA protein crosslinks are resolved through self-reversal, which is crucial for managing ssDNA abasic sites and maintaining genome stability.