Targeting RAD52 overcomes PARP inhibitor resistance in preclinical Brca2-deficient ovarian cancer model
Yukihide Ota, Vijayalaxmi G. Gupta, Bisiayo Fashemi, Moreniola Akande, Elizabeth Babu, Prasanth Thuthika, Maia Lina Elizagaray, Lulu Sun, Brooke E. Sanders, Lindsay M. Kuroki, Carolyn Kay McCourt, Andrea R. Hagemann, Ian S. Hagemann, Premal H. Thaker, David Gardner Mutch, , Dineo Khabele
This study identifies RAD52 as a target to overcome PARP inhibitor resistance in BRCA2-deficient ovarian cancer by showing its role in DNA repair and demonstrating synergistic effects with PARP inhibitors.
bioRxiv · Sep 24, 2025 · PreprintCancer Biology