Author

Prasanth Thuthika

Washington University in St. Louis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Andrea R. HagemanniD· 2 shared Brooke E. SandersiD· 2 shared Carolyn Kay McCourtiD· 2 shared David Gardner MutchiD· 2 shared Dineo KhabeleiD· 2 shared Ian S. HagemanniD· 2 shared Lindsay M. KurokiiD· 2 shared Mary Margaret MulleniD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Andrea R. HagemannORCID

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2 papers

Recent·Most cited

Targeting RAD52 overcomes PARP inhibitor resistance in preclinical Brca2-deficient ovarian cancer model

Yukihide Ota, Vijayalaxmi G. Gupta, Bisiayo Fashemi, Moreniola Akande, Elizabeth Babu, Prasanth Thuthika, Maia Lina Elizagaray, Lulu Sun, Brooke E. Sanders, Lindsay M. Kuroki, Carolyn Kay McCourt, Andrea R. Hagemann, Ian S. Hagemann, Premal H. Thaker, David Gardner Mutch, , Dineo Khabele

This study identifies RAD52 as a target to overcome PARP inhibitor resistance in BRCA2-deficient ovarian cancer by showing its role in DNA repair and demonstrating synergistic effects with PARP inhibitors.

bioRxiv · Sep 24, 2025 · PreprintCancer Biology

Targeting the COP9 signalosome overcomes platinum resistance in ovarian cancer through two distinct genome stability mechanisms

Elena Lomonosova, Megan Loeb, Kevin Rodriguez, Lilian N. van Biljon, Joshua D. Brill, Angela M. Schab, Margaret Minett, Jaeden Barron, Maya Bittner, Jiyoung Park, Rebecca Drexler, Carmen Sandoval, Alyssa Oplt, Eden Gallup, Prasanth Thuthika, , Mary Margaret Mullen

The paper identifies COPS5 as a therapeutic target for overcoming platinum resistance in ovarian cancer by inhibiting nucleotide excision repair and interstrand crosslink repair.

bioRxiv · Aug 4, 2025 · PreprintCancer Biology