Antigen presentation requirements for effective cDC1-based cancer immunotherapy
Josue Estiven Pineda, Tomoyuki Minowa, Li Shen, Yifan Zhou, Allison M. Dyevoich, Bhakti Patel, Sarah M. Schneider, Sunita Keshari, Akata Saha, Morgan Riba, Jing Wang, Stephanie S. Watowich, Matthew M. Gubin
This study shows that in vitro-derived cDC1s resemble tumor-infiltrating DCs and that MHC-I and MHC-II antigen presentation by these cells is essential for effective cancer immunotherapy.
The Journal of Immunology · Aug 1, 2026Peer-reviewedImmunology