Matthew M. Gubin

This study shows that in vitro-derived cDC1s resemble tumor-infiltrating DCs and that MHC-I and MHC-II antigen presentation by these cells is essential for effective cancer immunotherapy.

The paper constructs an integrated atlas of tumor-infiltrating dendritic cells across species and immunotherapy conditions, revealing conserved activation states and spatial reorganization in response to therapy.

The paper identifies tetrads as a multicellular immune unit that correlates with antitumor immunity and response to checkpoint blockade in mouse and human tumors.

This study identifies Bhlhe40 as a key regulator of T cell effector differentiation, showing distinct roles in CD4 and CD8 T cells for anti-PD-1 and anti-CTLA-4 therapies.

The paper constructs an immune cell knowledge graph (ICKG) using AI to annotate immunological gene sets more accurately than existing methods.

This study compares neoantigen vaccines and immune checkpoint therapies, finding they use distinct and overlapping mechanisms, with combined use showing superior efficacy.

The paper constructs immune-specific gene sets using non-negative matrix factorization on bulk RNA-seq data to improve immune subtype analysis and ICB response prediction.