Chromatin assembly at replication forks enables differentiation of human iPSCs
Jane Wright, Hao Jiang, Susanne Bandau, Simone Di Sanzo, Lindsay Davidson, Moritz Volker Albert, Angus I. Lamond, Constance Alabert
This study shows DNA replication enables chromatin changes during human iPSC differentiation by allowing protein access to nascent DNA, with H3K9 methylation and proteins like ERH and SETDB1 playing key roles.
bioRxiv · Jan 20, 2026 · PreprintCell Biology