DNA methylation links lagging strand replication to transposable element control
Nora Fajri, Manon Coulée, Antoine Pigeon, Sugith Babu Badugu, Aylin Seren Güller, Susanne Bandau, Hao Jiang, Angus I. Lamond, Laure Ferry, Max Greenberg, Pierre‐Antoine Defossez, Constance Alabert, Kumar Somyajit, Nataliya Petryk
The paper shows DNA methylation maintenance is linked to lagging-strand replication and TE control in mouse cells, with TE integration preferentially occurring on the lagging strand.
bioRxiv · Jun 23, 2026 · PreprintMolecular Biology