Author

Simone Di Sanzo

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Constance AlabertiD· 2 shared Susanne BandauiD· 2 shared Aleksandar BartolomeiD· 1 shared Alessandro CellerinoiD· 1 shared Alessandro Ori‬‬iD· 1 shared Angus I. LamondiD· 1 shared Bram PrevoiD· 1 shared Cinzia CaterinoiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

Constance AlabertORCID

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Author profile →

3 papers

Recent·Most cited

Chromatin assembly at replication forks enables differentiation of human iPSCs

Jane Wright, Hao Jiang, Susanne Bandau, Simone Di Sanzo, Lindsay Davidson, Moritz Volker Albert, Angus I. Lamond, Constance Alabert

This study shows DNA replication enables chromatin changes during human iPSC differentiation by allowing protein access to nascent DNA, with H3K9 methylation and proteins like ERH and SETDB1 playing key roles.

bioRxiv · Jan 20, 2026 · PreprintCell Biology

RIF1 orchestrates a multi-step restoration of post-replicative H3K9me3

Naiming Chen, Susanne Bandau, Reshma Ravindran Nair Pushkala Kumari, Bram Prevo, Takayo Sasaki, Shaun Webb, Simone Di Sanzo, David Shapira, Moritz Voelker-Albert, David M. Gilbert, Constance Alabert, Sara B.C. Buonomo

This study identifies RIF1's role in restoring H3K9me3 post-replication by facilitating SUV39H1, HP1, and PP1 recruitment and restraining Aurora kinase activity.

bioRxiv · Jul 14, 2025 · PreprintCell Biology

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

Erika Kelmer Sacramento, Joanna M Kirkpatrick, Mariateresa Mazzetto, Mario Baumgart, Aleksandar Bartolome, Simone Di Sanzo, Cinzia Caterino, Michele Sanguanini, Nikoletta Papaevgeniou, Maria Lefaki, Dorothee Childs, Sara Bagnoli, Eva Terzibasi Tozzini, Domenico Di Fraia, Natalie Romanov, , Alessandro Ori‬‬

This study shows that reduced proteasome activity in aging brains leads to ribosome stoichiometry loss and aggregation, increasing mortality risk in killifish.

Molecular Systems Biology · Jun 1, 2020Peer-reviewedSystems Biology