Coffee remodels the global histone acetylation landscape with reduced H3K27ac at the MYC promoter
Yangsu Cho, Makiko Miyota-Yui, Yaeko Nakajima‐Takagi, Takako Yokomizo, Motohiko Oshima, Atsushi Iwama, Kazumasa Aoyama
This study shows coffee reduces histone acetylation, particularly H3K27ac at the MYC promoter, leading to suppression of the MYC transcriptional program and inhibition of cancer cell proliferation.
bioRxiv · Aug 3, 2026 · PreprintMolecular Biology