Molecular BiologybioRxivPreprint
Coffee remodels the global histone acetylation landscape with reduced H3K27ac at the MYC promoter
Yangsu Cho, Makiko Miyota-Yui, Yaeko Nakajima‐Takagi…·Kazumasa Aoyama
This study shows coffee reduces histone acetylation, particularly H3K27ac at the MYC promoter, leading to suppression of the MYC transcriptional program and inhibition of cancer cell proliferation.