Atsushi Iwama

This study identifies BRM as a critical regulator of bone marrow sinusoidal niche integrity and hematopoietic regeneration, showing that its decline with age contributes to niche dysfunction and hematopoietic aging.

This study shows coffee reduces histone acetylation, particularly H3K27ac at the MYC promoter, leading to suppression of the MYC transcriptional program and inhibition of cancer cell proliferation.

The paper develops a DNA barcoding-based method to analyze HSC daughter cell pairs, revealing biased division patterns toward symmetric divisions and linking these to molecular features.

This study identifies macrophage fragment adhesion as a marker to distinguish dormant hematopoietic stem cells from proliferative ones across the lifespan.

This paper introduces SCALE-CLIP, a method to generate comparable RBP binding maps, and defines a positional and combinatorial regulatory code for alternative splicing.

This study shows that activating YAP/TAZ improves bone marrow niche recovery and hematopoietic regeneration after myeloablative stress.

This study shows that ASXL1 mutations in mice promote atherosclerosis by dysregulating innate immunity through impaired inhibition of NF-κB signaling.

This study identifies Rasip1 as a downstream target of Sox17 that enhances hematopoietic activity in intra-aortic hematopoietic clusters of midgestation mouse embryos.

The paper identifies PLZF's role in limiting enhancer activity during hematopoietic progenitor aging by targeting H3K27ac.