Synthetic BiologyCellPeer-reviewed
Scalable continuous evolution of genes at mutation rates above genomic error thresholds
Arjun Ravikumar, Garri A. Arzumanyan, Muaeen K.A. Obadi…·Chang C. Liu
This paper introduces OrthoRep, a system for high-throughput directed evolution of genes in yeast, demonstrating its ability to evolve drug-resistant malarial DHFRs and reveal complex fitness landscapes.
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