Author

Alex A. Javanpour

University of California, Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:yeast· 4 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Organism:E. coli· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein design· 1 Assay:proteomics· 1

Frequent Co-Authors

Chang C. LiuiD· 4 shared Andrew D. HansoniD· 1 shared Arjun Ravikumar· 1 shared Christopher R. ReischiD· 1 shared Emil D. JenseniD· 1 shared Francesca AmbriiD· 1 shared Garri A. Arzumanyan· 1 shared Jay D. KeaslingiD· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersSynthetic Biology

Chang C. LiuORCID

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4 papers

Recent·Most cited

Evolving small-molecule biosensors with improved performance and reprogrammed ligand specificity using OrthoRep

Alex A. Javanpour, Chang C. Liu

This study uses OrthoRep to evolve biosensors with improved dynamic range and reprogrammed ligand specificity for metabolic pathway engineering.

ACS Synthetic Biology · Oct 1, 2021Peer-reviewedSynthetic Biology

Integrating continuous hypermutation with high-throughput screening for optimization of cis,cis-muconic acid production in yeast

Emil D. Jensen, Francesca Ambri, Marie B. Bendtsen, Alex A. Javanpour, Chang C. Liu, Michael Krogh Jensen, Jay D. Keasling

The paper develops a directed evolution workflow combining OrthoRep and a transcription factor-based biosensor to optimize cis,cis-muconic acid production in yeast, achieving >13-fold higher titers.

Microbial Biotechnology · Mar 1, 2021Peer-reviewedSynthetic Biology

Potential For Applying Continuous Directed Evolution To Plant Enzymes

Jorge D. García-García, Jaya Joshi, Jenelle A. Patterson, Lidimarie Trujillo Rodríguez, Christopher R. Reisch, Alex A. Javanpour, Chang C. Liu, Andrew D. Hanson

The paper discusses two systems for continuous directed evolution of enzymes and tests their adaptation for plant enzyme engineering.

bioRxiv · Aug 26, 2020 · PreprintSynthetic Biology

Scalable continuous evolution of genes at mutation rates above genomic error thresholds

Arjun Ravikumar, Garri A. Arzumanyan, Muaeen K.A. Obadi, Alex A. Javanpour, Chang C. Liu

This paper introduces OrthoRep, a system for high-throughput directed evolution of genes in yeast, demonstrating its ability to evolve drug-resistant malarial DHFRs and reveal complex fitness landscapes.

Cell · Nov 8, 2018Peer-reviewedSynthetic Biology