RNA-programmable cell type monitoring and manipulation in the human cortex with CellREADR
Elizabeth A. Matthews, Jeffrey B. Russ, Yongjun Qian, Shengli Zhao, Peyton Thompson, Muhib Methani, Matthew L. Vestal, Z. Josh Huang, Derek G. Southwell
The paper introduces CellREADR, an RNA sensor-effector technology for targeting and manipulating specific human cortical neuron types, validated through histological, electrophysiological, and transcriptomic methods.
Cell Reports · Jul 22, 2025Peer-reviewedNeuroscience