Derek G. Southwell

This study investigates how sleep spindles interact with epileptic activity in thalamocortical circuits, finding bidirectional relationships and suggesting spindles stabilize network stability.

This study shows that sleep fragmentation increases local epileptic activity in specific brain regions without affecting broader network propagation.

This paper identifies distinct neural mechanisms for speech planning and execution using intracranial recordings.

This paper shows that speech BCIs can be trained on combined patient data by aligning neural data to a shared latent space, improving decoding performance compared to patient-specific models.

This study analyzes thalamic interictal events during NREM sleep in patients with focal epilepsy, finding associations between specific thalamic activity patterns and surgical outcomes.

This paper demonstrates that attenuated virotherapy with PVSRIPO reprograms microglia to clear neurotoxic debris and enhance immune surveillance in mouse models.

The paper develops an inducible barcoded rabies virus to study neuronal circuit development at single-cell and spatial resolution in mice, revealing developmental connectivity patterns and constructing in silico circuit models.

The paper introduces CRISPR-rabies virus (CRV) to enable precise circuit-level gene modulation in neurons, demonstrating its ability to regulate synaptic transmission in the hippocampus.

The paper introduces CellREADR, an RNA sensor-effector technology for targeting and manipulating specific human cortical neuron types, validated through histological, electrophysiological, and transcriptomic methods.

This study improves speech decoding accuracy using high-resolution ECoG recordings, achieving better phoneme decoding than standard methods.

This paper introduces CellREADR, a programmable RNA sensing technology that detects and manipulates cell types via RNA editing, demonstrating its use in mouse and human brain tissues.