Elizabeth A. Matthews

The paper develops an inducible barcoded rabies virus to study neuronal circuit development at single-cell and spatial resolution in mice, revealing developmental connectivity patterns and constructing in silico circuit models.

The paper introduces CRISPR-rabies virus (CRV) to enable precise circuit-level gene modulation in neurons, demonstrating its ability to regulate synaptic transmission in the hippocampus.

The paper introduces CellREADR, an RNA sensor-effector technology for targeting and manipulating specific human cortical neuron types, validated through histological, electrophysiological, and transcriptomic methods.

This paper introduces CellREADR, a programmable RNA sensing technology that detects and manipulates cell types via RNA editing, demonstrating its use in mouse and human brain tissues.

The paper investigates glutamate spread in the neuropil using optical reporters and finds that glutamate can activate AMPA and NMDA receptors at distances up to 2 micrometers from the release site.