An efficient opal-suppressor tryptophanyl pair creates new routes for simultaneously incorporating up to three distinct noncanonical amino acids into proteins in mammalian cells
Arianna O. Osgood, Yunan Zheng, Soumya Jyoti Singha Roy, Nikolaos Biris, Myer Hussain, Conor Loynd, Delilah Jewel, James S. Italia, Abhishek Chatterjee
This paper introduces an efficient method to incorporate up to three distinct noncanonical amino acids into proteins in mammalian cells using a combination of orthogonal aaRS/tRNA pairs.
Angewandte Chemie International Edition · Mar 11, 2023Peer-reviewedSynthetic Biology