Soumya Jyoti Singha Roy

A facile chemical strategy to synthesize precise AAV-protein conjugates for targeted gene delivery

This paper describes a chemical strategy to create AAV-protein conjugates for targeted gene delivery, showing efficient and selective transduction of HER2+ cancer cells with minimal off-target effects.

Directed evolution of a bacterial leucyl tRNA in mammalian cells for enhanced noncanonical amino acid mutagenesis

This paper improves the efficiency of noncanonical amino acid incorporation in mammalian cells by evolving tRNAEcLeu through directed evolution in mammalian cells.

An efficient opal-suppressor tryptophanyl pair creates new routes for simultaneously incorporating up to three distinct noncanonical amino acids into proteins in mammalian cells

This paper introduces an efficient method to incorporate up to three distinct noncanonical amino acids into proteins in mammalian cells using a combination of orthogonal aaRS/tRNA pairs.

A facile platform to engineer E. coli tyrosyl-tRNA synthetase adds new chemistries to the eukaryotic genetic code, including a phosphotyrosine mimic

This paper describes an engineered E. coli tyrosyl-tRNA synthetase system that enables the incorporation of new noncanonical amino acids into eukaryotic cells.