BiochemistryFrontiers in ImmunologyPeer-reviewed
Polymorphic positions 349 and 725 of the autoimmunity-protective allotype 10 of ER aminopeptidase 1 are key in determining its unique enzymatic properties
Galateia Georgaki, Anastasia Mpakali, Myrto Trakada…·Efstratios Stratikos
This study investigates the enzymatic properties of ERAP1 allotype 10, showing that polymorphisms V349M and Q725R significantly affect its activity, kinetics, and thermodynamics compared to allotype 1.
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