Author

Anastasia Mpakali

National and Kapodistrian University of AthensORCID 0000-0003-0869-9680Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Efstratios StratikosiD· 2 shared Galateia GeorgakiiD· 2 shared Alberto Buson· 1 shared Alison D. Findlay· 1 shared Athanasios PapakyriakouiD· 1 shared Dieter W. HamprechtiD· 1 shared François‐Xavier MauvaisiD· 1 shared Jonathan S. FootiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Efstratios StratikosORCID

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2 papers

Recent·Most cited

BiochemistryFrontiers in ImmunologyPeer-reviewedOct 18, 2024

Polymorphic positions 349 and 725 of the autoimmunity-protective allotype 10 of ER aminopeptidase 1 are key in determining its unique enzymatic properties

Galateia Georgaki, Anastasia Mpakali, Myrto Trakada…·Efstratios Stratikos

This study investigates the enzymatic properties of ERAP1 allotype 10, showing that polymorphisms V349M and Q725R significantly affect its activity, kinetics, and thermodynamics compared to allotype 1.

1 citation

humanproteomics

𝕏 PostBluesky

BiochemistryProtein SciencePeer-reviewedAug 21, 2024

Stabilization of the open conformation of Insulin-Regulated Aminopeptidase by a novel substrate-selective small molecule inhibitor

Anastasia Mpakali, Galateia Georgaki, Alberto Buson…·Efstratios Stratikos

This paper identifies a nanomolar inhibitor of IRAP that stabilizes its open conformation, revealing a conformation-specific mechanism of action and insights into its catalytic cycle.

4 citations

experimental assaydrug response / drug discovery

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