N. Aliakbarinodehi

Time Resolved Inspection of Ionizable-Lipid Facilitated Lipid Nanoparticle Disintegration and Cargo Release at an Endosomal Membrane Mimic

This study uses TIRF imaging to examine pH-induced LNP fusion and mRNA release, showing delayed fusion onset and rapid cargo escape, with implications for optimizing mRNA delivery.

Time evolution of PEG-shedding and serum protein coronation determines the cell uptake kinetics and delivery of lipid nanoparticle formulated mRNA

This study models protein corona formation on LNPs and identifies time-dependent steps that affect their uptake and mRNA delivery, showing that pre-incubation in serum can eliminate a lag-time.