M. M. Stevens

Bioactive coatings on 3D printed scaffolds for bone regeneration: Use of Laponite(R) to deliver BMP-2 in an ovine femoral condyle defect model

This study evaluates Laponite(R)-coated scaffolds for delivering BMP-2 in a large animal bone defect model, showing enhanced bone formation compared to uncoated scaffolds.

Bioactive coatings on 3D printed polycaprolactone scaffolds for bone regeneration: a novel murine femur defect model for examination of the biomaterial capacity for repair.

This study evaluates bioactive coatings on 3D printed PCL-TMA900 scaffolds for bone regeneration using a murine femur defect model, finding that Laponite/BMP-2 coating significantly promotes bone formation without heterotopic bone formation.

Bioactive coatings on 3D printed scaffolds for bone regeneration: Use of Laponite™ to deliver BMP-2 for bone tissue engineering - progression through in vitro, chorioallantoic membrane assay and murine subcutaneous model validation.

This paper evaluates Laponite-coated scaffolds for delivering BMP-2 to enhance bone regeneration, showing effective osteoinduction in vitro and in vivo with delayed use.

Bioactive coatings on 3D printed scaffolds for bone regeneration: Translation from in vitro to in vivo models and the impact of material properties and growth factor concentration.

This study evaluates bioactive coatings on 3D-printed PCL-TMA scaffolds for bone regeneration, showing in vitro osteogenic response but no significant in vivo bone formation.

Competitive Amplification Networks enable molecular pattern recognition with PCR

This paper introduces Competitive Amplification Networks (CANs) to enable the analysis of entire gene expression signatures in a single PCR reaction, achieving perfect diagnostic agreement with gold-standard methods.

Time evolution of PEG-shedding and serum protein coronation determines the cell uptake kinetics and delivery of lipid nanoparticle formulated mRNA

This study models protein corona formation on LNPs and identifies time-dependent steps that affect their uptake and mRNA delivery, showing that pre-incubation in serum can eliminate a lag-time.

Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane

This study reveals that colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane, not the outer membrane, and shows that murepavadin can enhance its efficacy.

Artificial Antigen Presenting Cells for Detection and Desensitisation of Auto-reactive T cells Associated with Type 1 Diabetes

This paper develops artificial antigen presenting cells (aAPCs) to detect and desensitize autoreactive T cells in type 1 diabetes, showing effectiveness in human and mouse models.

Driving Hierarchical Collagen Fiber Formation for Functional Tendon, Ligament, and Meniscus Replacement

This study shows that restrained cell-seeded collagen gels can produce native-sized, organized collagen fibers for tendon, ligament, and meniscus tissues in vitro.

Linking single-cell measurements of mass, growth rate, and gene expression

This paper introduces a microfluidic platform that links single-cell biophysical measurements with scRNA-seq to study gene expression related to cell mass and growth rate.