MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2
A. Martinez de Paz, L. Khajavi, H. Martin, R. Claveria-Gimeno, S. tom Dieck, M. S. Cheema, J. V. Sanchez-Mut, M. Moksa, A. Carles, N. Brodie, T. I. Sheikh, M. Freeman, E. Petrotchenko, C. Borchers, E. Schuman, , J. Ausio
This study compares MeCP2-E1 and E2 isoforms, showing differences in DNA binding, protein interactions, and dynamic behavior, with implications for their functional roles in chromatin regulation.
bioRxiv · Aug 17, 2018Biochemistry