Author

H. Martin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:proteomics· 4 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Assay:protein structure· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. E. Malnou· 3 shared A. M. Diaz-Rovira· 2 shared G. Cartron· 2 shared G. D'Angelo· 2 shared G. Raposo· 2 shared I. Hurbain· 2 shared J. Izopet· 2 shared J.-M. Mansuy· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCell Biology

C. E. Malnou

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Cytosolic pH controls fungal MAPK signaling and pathogenicity

T. R. Fernandes, M. Mariscal Gomez, A. Serrano, D. Segorbe, T. Fernandez-Acero, H. Martin, D. Turra, A. Di Pietro

This study shows that cytosolic pH controls MAPK signaling and pathogenicity in fungi by modulating phosphorylation levels and sphingolipid metabolism.

bioRxiv · Oct 23, 2022Microbiology

Are Deep Learning Structural Models Sufficiently Accurate for Virtual Screening? Application of Docking Algorithms to AlphaFold2 Predicted Structures

A. M. Diaz-Rovira, H. Martin, T. Beuming, L. Diaz, V. Guallar, S. S. Ray

This study evaluates the accuracy of AlphaFold2 structures for virtual screening, finding that out-of-the-box models are insufficient for hit-finding in low sequence identity targets and suggest post-processing improvements.

bioRxiv · Aug 18, 2022Biochemistry

Are Deep Learning Structural Models Sufficiently Accurate for Free Energy Calculations? Application of FEP+ to AlphaFold2 Predicted Structures

T. Beuming, H. Martin, A. M. Diaz-Rovira, L. Diaz, V. Guallar, S. S. Ray

The paper assesses if AlphaFold2 structures are accurate enough for FEP calculations in drug discovery, finding they perform comparably to X-ray structures in most cases.

bioRxiv · Aug 16, 2022Biochemistry

Human Cytomegalovirus modifies placental small extracellular vesicle secretion and composition towards a proviral phenotype to enhance infection of fetal recipient cells

M. Bergamelli, H. Martin, Y. Aubert, J.-M. Mansuy, M. Marcellin, O. Burlet-Schiltz, I. Hurbain, G. Raposo, J. Izopet, T. Fournier, A. Benchoua, M. Benard, M. Groussolles, G. Cartron, Y. Tanguy le Gac, , C. E. Malnou

This study shows hCMV infection alters placental sEVs to promote viral spread to fetal cells.

bioRxiv · Nov 18, 2021Cell Biology

Human cytomegalovirus infection changes the pattern of surface markers of small extracellular vesicles isolated from first trimester placental histocultures

M. Bergamelli, H. Martin, M. Benard, J. Ausseil, J.-M. Mansuy, I. Hurbain, M. Mouysset, M. Groussolles, G. Cartron, Y. Tanguy le Gac, N. Moinard, E. Suberbielle, J. Izopet, C. Tscherning, G. Raposo, , C. E. Malnou

This study examines how human cytomegalovirus infection alters surface markers on placental-derived small extracellular vesicles from first trimester histocultures.

Frontiers in Cell and Developmental Biology · Sep 10, 2021Peer-reviewedCell Biology

A high-content screen profiles cytotoxic microRNAs in pediatric and adult glioblastoma cells and identifies miR-1300 as a potent inducer of cytokinesis failure

M. Boissinot, H. King, M. Adams, J. Higgins, T. A. Ward, L. P. Steele, D. Tams, R. Morton, E. Polson, B. da Silva, A. P. Droop, J. L. Hayes, H. Martin, P. Laslo, E. E. Morrison, , S. C. Short

This study identifies miR-1300 as a potent cytotoxic microRNA in glioblastoma cells, causing cytokinesis failure and apoptosis, with potential therapeutic applications.

bioRxiv · Oct 1, 2019 · PreprintCancer Biology

MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2

A. Martinez de Paz, L. Khajavi, H. Martin, R. Claveria-Gimeno, S. tom Dieck, M. S. Cheema, J. V. Sanchez-Mut, M. Moksa, A. Carles, N. Brodie, T. I. Sheikh, M. Freeman, E. Petrotchenko, C. Borchers, E. Schuman, , J. Ausio

This study compares MeCP2-E1 and E2 isoforms, showing differences in DNA binding, protein interactions, and dynamic behavior, with implications for their functional roles in chromatin regulation.

bioRxiv · Aug 17, 2018Biochemistry